HCID 67996182, compound → HCID 67996049, compound

HRID 1615152Notes

Reaction equation

HRID 1615152 reaction equation
[OH:1][C:2]1([CH2:15][CH:16]=O)[CH2:14][CH2:13][C:5]2([O:10][CH2:9][C:8]([CH3:12])([CH3:11])[CH2:7][O:6]2)[CH2:4][CH2:3]1.[F:18][CH:19]([F:29])[C:20]1[CH:25]=[CH:24][C:23]([C@@H:26]([NH2:28])[CH3:27])=[CH:22][CH:21]=1>>[F:18][CH:19]([F:29])[C:20]1[CH:21]=[CH:22][C:23]([C@@H:26]([NH:28][CH2:16][CH2:15][C:2]2([OH:1])[CH2:3][CH2:4][C:5]3([O:10][CH2:9][C:8]([CH3:12])([CH3:11])[CH2:7][O:6]3)[CH2:13][CH2:14]2)[CH3:27])=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 67996182HCID 67996182, compoundHCID 86668369(9-Hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde

Product 1

HCID 67996049HCID 67996049, compoundYield 77%

Procedure

The title compound is prepared from (9-hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde and (S)-1-(4-difluoromethyl-phenyl)-ethylamine following a procedure analogous to that described in Step 3 of Intermediate 2. Yield: 77% of theory; LC (method 8): tR=1.10 min; Mass spectrum (ESI+): m/z=398 [M+H]+.

Sources & evidence

ORD record
ord-9607c5113c4b48cfa70d5743d104cdb9
Source dataset
uspto-grants-2014_07
Patent number
US08765744B2

Reaction notes

Loading…