(αS)-2-Chloro-α-methylbenzenemethanamine → HCID 70496706, compound

HRID 1615154Notes

Reaction equation

HRID 1615154 reaction equation
[OH:1][C:2]1([CH2:15][CH:16]=O)[CH2:14][CH2:13][C:5]2([O:10][CH2:9][C:8]([CH3:12])([CH3:11])[CH2:7][O:6]2)[CH2:4][CH2:3]1.[Cl:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[C@@H:25]([NH2:27])[CH3:26]>>[Cl:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[C@@H:25]([NH:27][CH2:16][CH2:15][C:2]1([OH:1])[CH2:3][CH2:4][C:5]2([O:6][CH2:7][C:8]([CH3:11])([CH3:12])[CH2:9][O:10]2)[CH2:13][CH2:14]1)[CH3:26]

Participants

3

Reactant 2

HCID 1551199(αS)-2-Chloro-α-methylbenzenemethanamineHCID 86668369(9-Hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde

Product 1

HCID 70496706HCID 70496706, compoundYield 89%

Procedure

The title compound is prepared from (9-hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde and (S)-1-(2-chloro-phenyl)-ethylamine following a procedure analogous to that described in Step 3 of Intermediate 2. Yield: 89% of theory; LC (method 8): tR=1.18 min; Mass spectrum (ESI+): m/z=382/384 (Cl) [M+H]+.

Sources & evidence

ORD record
ord-feb0b26b215243eab7b9a08940d4d71c
Source dataset
uspto-grants-2014_07
Patent number
US08765744B2

Reaction notes

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