(1S)-1-phenylpropan-1-amine → HCID 70498234, compound

HRID 1615155Notes

Reaction equation

HRID 1615155 reaction equation
[OH:1][C:2]1([CH2:15][CH:16]=O)[CH2:14][CH2:13][C:5]2([O:10][CH2:9][C:8]([CH3:12])([CH3:11])[CH2:7][O:6]2)[CH2:4][CH2:3]1.[C:18]1([C@@H:24]([NH2:27])[CH2:25][CH3:26])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH3:11][C:8]1([CH3:12])[CH2:9][O:10][C:5]2([CH2:4][CH2:3][C:2]([CH2:15][CH2:16][NH:27][C@H:24]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)[CH2:25][CH3:26])([OH:1])[CH2:14][CH2:13]2)[O:6][CH2:7]1

Participants

3

Reactant 2

HCID 6993773(1S)-1-phenylpropan-1-amineHCID 86668369(9-Hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde

Product 1

HCID 70498234HCID 70498234, compoundYield 50%

Procedure

The title compound is prepared from (9-hydroxy-3,3-dimethyl-1,5-dioxa-spiro[5.5]undec-9-yl)-acetaldehyde and (S)-1-phenyl-propylamine following a procedure analogous to that described in Step 3 of Intermediate 2. Yield: 50% of theory; LC (method 8): tR=1.16 min; Mass spectrum (ESI+): m/z=362 [M+H]+.

Sources & evidence

ORD record
ord-5969ccb1707f45ba95fc44edb647bb70
Source dataset
uspto-grants-2014_07
Patent number
US08765744B2

Reaction notes

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