(S)-(-)-1-(4-chlorophenyl)ethylamine → HCID 86668373, compound

HRID 1615159Notes

Reaction equation

HRID 1615159 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]([NH:5][C:6]1([CH2:16][CH:17]=O)[CH2:15][CH2:14][C:9]2([O:13][CH2:12][CH2:11][O:10]2)[CH2:8][CH2:7]1)=[O:4].[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([C@@H:28]([NH2:30])[CH3:29])=[CH:24][CH:23]=1>>[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([C@@H:28]([NH:30][CH2:17][CH2:16][C:6]2([NH:5][C:3](=[O:4])[C:2]([F:19])([F:20])[F:1])[CH2:15][CH2:14][C:9]3([O:13][CH2:12][CH2:11][O:10]3)[CH2:8][CH2:7]2)[CH3:29])=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 1550852(S)-(-)-1-(4-chlorophenyl)ethylamineHCID 86668374HCID 86668374, compound

Product 1

HCID 86668373HCID 86668373, compoundYield 75%

Procedure

The title compound is prepared from 2,2,2-trifluoro-N-[8-(2-oxo-ethyl)-1,4-dioxa-spiro[4.5]dec-8-yl]-acetamide and (S)-1-(4-chloro-phenyl)-ethylamine following a procedure analogous to that described in Step 3 of Intermediate 2. Yield: 75% of theory; LC (method 8): tR=1.10 min; Mass spectrum (ESI+): m/z=435/437 (Cl) [M+H]+.

Sources & evidence

ORD record
ord-ce9318f31f1e43fc9930c3c2d738103a
Source dataset
uspto-grants-2014_07
Patent number
US08765744B2

Reaction notes

Loading…