HCID 67996267, compound → HCID 70496882, compound

HRID 1615171Notes

Reaction equation

HRID 1615171 reaction equation
[CH3:1][N:2]([CH3:32])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([C@@H:17]([N:19]3[CH2:24][CH2:23][C:22]4([CH2:29][CH2:28][C:27](=[O:30])[CH2:26][CH2:25]4)[O:21][C:20]3=[O:31])[CH3:18])=[CH:13][CH:12]=2)=[CH:7][N:6]=1)=[O:4]>CO.O>[CH3:32][N:2]([CH3:1])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([CH:17]([N:19]3[CH2:24][CH2:23][C:22]4([CH2:25][CH2:26][CH:27]([OH:30])[CH2:28][CH2:29]4)[O:21][C:20]3=[O:31])[CH3:18])=[CH:13][CH:12]=2)=[CH:7][N:6]=1)=[O:4]

Participants

3

Reactant 1

HCID 67996267HCID 67996267, compound

Product 1

HCID 70496882HCID 70496882, compound

Reagents, catalysts & solvents 1

HCID 22242641Methanol--water (1/1)Solvent

Procedure

The title compound is prepared from 5-{4-[(S)-1-(2,9-dioxo-1-oxa-3-aza-spiro[5.5]undec-3-yl)-ethyl]-phenyl}-pyridine-2-carboxylic acid dimethylamide following a procedure analogous to that described in Example 22; after HPLC on reversed phase (methanol/water) the title compound is obtained in a ca. 1:1 mixture of cis- and trans-isomer. Yield: 53% of theory; LC (method 2): tR=1.58 min; Mass spectrum (ESI+): m/z=438 [M+H]+.

Sources & evidence

ORD record
ord-2820e2bb24b54ac6be0246c3753c3ec2
Source dataset
uspto-grants-2014_07
Patent number
US08765744B2

Reaction notes

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