N-(2-Oxoindolin-6-yl)acetamide → N-(2-oxoindolin-5-yl)acetamide

HRID 1615201Notes

Reaction equation

HRID 1615201 reaction equation
[O:1]=[C:2]1[CH2:10][C:9]2[C:4](=[CH:5][C:6](NC(=O)C)=[CH:7][CH:8]=2)[NH:3]1.NC1C=C2C(=CC=1)[NH:21][C:20](=[O:25])[CH2:19]2>>[O:1]=[C:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([NH:21][C:20](=[O:25])[CH3:19])[CH:8]=2)[NH:3]1

Participants

3

Reactant 2

HCID 2749839N-(2-Oxoindolin-6-yl)acetamideHCID 27732135-Amino-2-oxindole

Product 1

HCID 11206280N-(2-oxoindolin-5-yl)acetamide

Procedure

According to procedure for the synthesis of N-(2-oxoindolin-6-yl)acetamide, except substituting 5-aminoindolin-2-one (50 mg, 0.34 mmol), the title compound was prepared as a beige solid (46 mg, 71%). 1H NMR (400 MHz, CDCl3) δ 7.49 (s, 1H), 7.31 (d, J=7.0 Hz, 1H), 6.83 (d, J=8.0 Hz, 1H), 3.52 (s, 2H), 2.10 (s, 3H).

Sources & evidence

ORD record
ord-e2ebf2e21d9940a3b15d39adc5ecf0bc
Source dataset
uspto-grants-2014_07
Patent number
US08765748B2

Reaction notes

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