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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1615201Generated: October 31, 2026

N-(2-Oxoindolin-6-yl)acetamide → N-(2-oxoindolin-5-yl)acetamide

https://huagongshe.com/reaction/1615201

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(2-Oxoindolin-6-yl)acetamideHCID 2749839—
Reactant5-Amino-2-oxindoleHCID 2773213—
ProductN-(2-oxoindolin-5-yl)acetamideHCID 11206280—

Reaction Steps

According to procedure for the synthesis of N-(2-oxoindolin-6-yl)acetamide, except substituting 5-aminoindolin-2-one (50 mg, 0.34 mmol), the title compound was prepared as a beige solid (46 mg, 71%). 1H NMR (400 MHz, CDCl3) δ 7.49 (s, 1H), 7.31 (d, J=7.0 Hz, 1H), 6.83 (d, J=8.0 Hz, 1H), 3.52 (s, 2H), 2.10 (s, 3H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08765748B2
Source datasetuspto-grants-2014_07
ORD IDord-e2ebf2e21d9940a3b15d39adc5ecf0bc
Source noteuspto-grants-2014_07