HCID 10214443, compound → HCID 178485261, compound

HRID 1615225Notes

Reaction equation

HRID 1615225 reaction equation
[CH3:1][NH:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2)=[O:4].[NH:15]1[C:23]2[C:18](=[CH:19][CH:20]=[C:21]([CH:24]=O)[CH:22]=2)[CH:17]=[N:16]1>>[NH:15]1[C:23]2[C:18](=[CH:19][CH:20]=[C:21](/[CH:24]=[C:8]3/[C:9](=[O:14])[NH:10][C:11]4[C:7]/3=[CH:6][C:5]([C:3]([NH:2][CH3:1])=[O:4])=[CH:13][CH:12]=4)[CH:22]=2)[CH:17]=[N:16]1

Participants

3

Reactant 2

HCID 10214443HCID 10214443, compoundHCID 185383681H-Indazole-6-carbaldehyde

Product 1

HCID 178485261HCID 178485261, compound

Procedure

The title compound was synthesized from N-methyl-2-oxoindoline-5-carboxamide (11 mg, 0.0578 mmol) and 1H-indazole-6-carbaldehyde (10 mg, 0.0636 mmol) according to the method described for Example A1 to obtain 3.0 mg, 17%. 1H NMR (400 MHz, d6-DMSO) δ 13.33 (s, 1H), 10.88 (s, 1H), 8.24-8.22 (m, 1H), 8.18 (s, 2H), 7.93-7.88 (m, 2H), 7.84 (s, 1H), 7.72 (d, J=7.9 Hz, 1H), 7.46 (d, J=8.0 Hz, 1H), 6.91 (d, J=8.0 Hz, 1H), 2.68 (d, J=4.0 Hz, 3H); MS ESI 319.1 [M+H]+, calcd for [C18H14N4O2+H]+ 319.12.

Workup

  1. customto obtain 3.0 mg, 17%

Sources & evidence

ORD record
ord-8c2f1cd724a643ad972bbb2f3113e221
Source dataset
uspto-grants-2014_07
Patent number
US08765748B2

Reaction notes

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