HCID 71073900, compound → HCID 71073624, compound

Participants

Reaction Steps

The N-(4-(3-(1,2,4-triazol-1-yl)-propyl)-phenyl)-4-tert-butoxycarbonylaminopiperidine (180 mg, 0.47 mmol) obtained in Example 8(5) was dissolved in trifluoroacetic acid (5 ml) at 0° C., followed by stirring at room temperature for 1 hour. The reaction mixture was evaporated under reduced pressure, and the obtained residue was purified using medium-pressure silica gel flash column chromatography (NH silica gel, methanol:chloroform=1:9), thereby obtaining N-(4-(3-(1,2,4-triazol-1-yl)-propyl)-phenyl)-4-aminopiperidine (127 mg, 95%).

Provenance & Evidence