HCID 71073900, compound → HCID 71073624, compound

HRID 1615401Notes

Reaction equation

HRID 1615401 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][C:9]2[CH:14]=[CH:13][C:12]([N:15]3[CH2:20][CH2:19][CH:18]([NH:21]C(OC(C)(C)C)=O)[CH2:17][CH2:16]3)=[CH:11][CH:10]=2)[CH:5]=[N:4][CH:3]=[N:2]1>FC(F)(F)C(O)=O>[N:1]1([CH2:6][CH2:7][CH2:8][C:9]2[CH:10]=[CH:11][C:12]([N:15]3[CH2:16][CH2:17][CH:18]([NH2:21])[CH2:19][CH2:20]3)=[CH:13][CH:14]=2)[CH:5]=[N:4][CH:3]=[N:2]1

Participants

3

Reactant 1

HCID 71073900HCID 71073900, compound

Product 1

HCID 71073624HCID 71073624, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

The N-(4-(3-(1,2,4-triazol-1-yl)-propyl)-phenyl)-4-tert-butoxycarbonylaminopiperidine (180 mg, 0.47 mmol) obtained in Example 8(5) was dissolved in trifluoroacetic acid (5 ml) at 0° C., followed by stirring at room temperature for 1 hour. The reaction mixture was evaporated under reduced pressure, and the obtained residue was purified using medium-pressure silica gel flash column chromatography (NH silica gel, methanol:chloroform=1:9), thereby obtaining N-(4-(3-(1,2,4-triazol-1-yl)-propyl)-phenyl)-4-aminopiperidine (127 mg, 95%).

Workup

  1. customThe reaction mixture was evaporated under reduced pressure
  2. customthe obtained residue was purified

Sources & evidence

ORD record
ord-2da5f4bfdd474adc8ede9ce78b766d4f
Source dataset
uspto-grants-2014_07
Patent number
US08765750B2

Reaction notes

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