反应详情

This compound was prepared from tert-butyl 5-((diphenoxyphosphoryl)oxy)-2H-1,4-oxazine-4(3H)-carboxylate and 4-hydroxyphenylboronic acid using a procedure similar to that described in Example 2 (Steps 1-3a) above. The product was isolated as an off-white solid (44% yield); 1H-NMR (d6-DMSO) 1.37 (9H, s), 3.65 (2H, t), 4.05 (2H, t), 6.20 (1H, s), 6.68 (2H, d), 7.00 (2H, d), 9.25 (1H, s); 13C-NMR (CDCl3) 27.7, 41.7, 66.8, 114.7, 126.4, 131.4); MS ES(+) 222.1 (M+-tBu); Anal. Calcd for C15H19NO4: C, 64.97; H, 6.91; N, 5.05. Found: C, 64.59; H, 7.05; N, 4.85. IR λmax=3402, 1672 cm−1.