Hydrochloric Acid → HCID 68183276, compound

Participants

Reaction Steps

A mixture of methyl rel-(4R,5R)-4-(3,4-dichlorophenyl)-2-(morpholin-4-yl)-7-oxo-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-5-carboxylate (274.0 mg, 0.6208 mmol) in tetrahydrofuran (10.0 mL) and sodium hydroxide (4.50 mmol, 4.50 mmol) in water (4.50 g) was stirred at rt. After 4 h, the mixture was acidified by 1N HCl and the precipitate was collected as pure product (0.250 g, 94%). LCMS: (AA), ES+: 425, 427.

Provenance & Evidence