Hydrochloric Acid → HCID 68183276, compound

HRID 1615558Notes

Reaction equation

HRID 1615558 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C@H:9]2[C@H:14]([C:15]([O:17]C)=[O:16])[NH:13][C:12](=[O:19])[C:11]3[S:20][C:21]([N:23]4[CH2:28][CH2:27][O:26][CH2:25][CH2:24]4)=[CH:22][C:10]2=3)[CH:5]=[CH:6][C:7]=1[Cl:8].[OH-].[Na+].Cl>O1CCCC1.O>[Cl:1][C:2]1[CH:3]=[C:4]([C@H:9]2[C@H:14]([C:15]([OH:17])=[O:16])[NH:13][C:12](=[O:19])[C:11]3[S:20][C:21]([N:23]4[CH2:24][CH2:25][O:26][CH2:27][CH2:28]4)=[CH:22][C:10]2=3)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68183401HCID 68183401, compound

Product 1

HCID 68183276HCID 68183276, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of methyl rel-(4R,5R)-4-(3,4-dichlorophenyl)-2-(morpholin-4-yl)-7-oxo-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-5-carboxylate (274.0 mg, 0.6208 mmol) in tetrahydrofuran (10.0 mL) and sodium hydroxide (4.50 mmol, 4.50 mmol) in water (4.50 g) was stirred at rt. After 4 h, the mixture was acidified by 1N HCl and the precipitate was collected as pure product (0.250 g, 94%). LCMS: (AA), ES+: 425, 427.

Workup

  1. customthe precipitate was collected as pure product (0.250 g, 94%)

Sources & evidence

ORD record
ord-f5e1567b124c4ac2acce496ceb9a5015
Source dataset
uspto-grants-2014_07
Patent number
US08765746B2

Reaction notes

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