Phenylboronic Acid → HCID 73603214, compound

HRID 1615732Notes

Reaction equation

HRID 1615732 reaction equation
[C:1]1(B(O)O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:10][C:11]1[C:16]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[N:15][N:14]=[C:13]2[N:23]([CH2:27][CH2:28][N:29]3[CH2:33][CH2:32][CH2:31][CH2:30]3)[N:24]=[C:25](I)[C:12]=12>>[Cl:10][C:11]1[C:16]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[N:15][N:14]=[C:13]2[N:23]([CH2:27][CH2:28][N:29]3[CH2:33][CH2:32][CH2:31][CH2:30]3)[N:24]=[C:25]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[C:12]=12

Participants

3

Reactant 2

HCID 66827Phenylboronic AcidHCID 86717366HCID 86717366, compound

Product 1

HCID 73603214HCID 73603214, compound

Procedure

Compound 13 was synthesised according to Example 1, Step 8 using phenylboronic acid in place of 4-fluorophenylboronic acid and using 4-chloro-3-iodo-5-phenyl-1-(2-pyrrolidin-1-ylethyl)pyrazolo[3,4-c]pyridazine in place of 2-(4-chloro-3-iodo-5-phenyl-pyrazolo[3,4-c]pyridazin-1-yl)-1-[(3R)-3-fluoropyrrolidin-1-yl]ethanone.

Sources & evidence

ORD record
ord-0a7cfe2d7c6e4dcca613c8fa53fb349a
Source dataset
uspto-grants-2014_07
Patent number
US08765762B2

Reaction notes

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