反应详情

34.5 g (146.8 mmol) 3,5-difluorophenacylbromide, 30.6 g (440.4 mmol) hydroxylamine-hydrochloride, 44.0 ml of water and 320.0 mL methanol were stirred overnight at RT. The reaction mixture was concentrated by rotary evaporation using the rotary evaporator and mixed with 150 mL water and extracted twice with ethyl acetate. The combined organic phases were washed with water, dried and evaporated to dryness by rotary evaporation.

1. concentrationThe reaction mixture was concentrated by rotary evaporation
2. customthe rotary evaporator
3. additionmixed with 150 mL water
4. extractionextracted twice with ethyl acetate
5. washThe combined organic phases were washed with water
6. customdried
7. customevaporated to dryness by rotary evaporation