HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorosuccinimide → 5-amino-6-chloro-1,3-dihydrospiro[inden-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | 5-amino-1,3-dihydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one | HCID 59166722 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-amino-6-chloro-1,3-dihydrospiro[inden-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one | HCID 68761776 | — |
Reaction Steps
0.50 g (2.0 mmol) 5-amino-1,3-dihydrospiro[inden-2,3′-pyrrolo[2,3-b]pyridin]-2′(1′H)-one in 20 ml DCM were combined with 0.27 g (2 mmol) N-chlorosuccinimide versetzt and stirred for 5 h at RT. The mixture was evaporated down and the residue was purified by HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765763B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-391fef2657134cf28b17bf790624c72c |
| Source note | uspto-grants-2014_07 |