反应详情

0.26 g (0.6 mmol) 2-(1-(tert-butoxycarbonyl)-3-(4-fluorophenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)ethanoic acid in 10 ml DMF were combined with 0.46 g (1.2 mmol) HATU and 0.20 ml (1.4 mmol) TEA and stirred for 10 min at RT. Then 0.17 g (0.66 mmol) (S)-5-amino-1,3-dihydrospiro[inden-2,3′-pyrrolo[2,3-b]pyridin]-2′(1′H)-one were added and the mixture was stirred overnight at RT. The reaction mixture was poured onto water. The precipitate formed was suction filtered, washed with water and dried.

1. stirringthe mixture was stirred overnight at RT
2. additionThe reaction mixture was poured onto water
3. customThe precipitate formed
4. filtrationfiltered
5. washwashed with water
6. customdried