Hydrochloric Acid → (R)-methyl 2-(3-(3,5-difluorophenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)acetate hydrochloride

HRID 1615765Notes

Reaction equation

HRID 1615765 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C@H:9]2[N:14]([CH2:15][C:16]([O:18][CH3:19])=[O:17])[C:13](=[O:20])[C:12]3([CH2:26][O:25][CH2:24][CH2:23][O:22][CH2:21]3)[N:11](C(OC(C)(C)C)=O)[CH2:10]2)[CH:5]=[C:6]([F:8])[CH:7]=1.[ClH:34]>>[ClH:34].[F:8][C:6]1[CH:5]=[C:4]([C@H:9]2[N:14]([CH2:15][C:16]([O:18][CH3:19])=[O:17])[C:13](=[O:20])[C:12]3([CH2:21][O:22][CH2:23][CH2:24][O:25][CH2:26]3)[NH:11][CH2:10]2)[CH:3]=[C:2]([F:1])[CH:7]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 68154574tert-butyl (R)-3-(3,5-difluoro-phenyl)-4-methoxycarbonylmethyl-5-oxo-8,11-dioxa-1,4-diaza-spiro[5.6]dodecane-1-carboxylate

Product 1

HCID 68154674(R)-methyl 2-(3-(3,5-difluorophenyl)-5-oxo-8,11-dioxa-1,4-diazaspiro[5.6]dodecan-4-yl)acetate hydrochloride

Conditions

Temperature
50 °C

Procedure

0.13 g (0.28 mmol) tert-butyl (R)-3-(3,5-difluoro-phenyl)-4-methoxycarbonylmethyl-5-oxo-8,11-dioxa-1,4-diaza-spiro[5.6]dodecane-1-carboxylate were combined with 20 ml of a 1M methanolic hydrochloric acid solution and stirred for 2 h at 50° C. The reaction mixture was concentrated by rotary evaporation and further reacted without any further purification.

Workup

  1. concentrationThe reaction mixture was concentrated by rotary evaporation
  2. customfurther reacted without any further purification

Sources & evidence

ORD record
ord-f635bd57fb15454dbdaabded8c7ea9e0
Source dataset
uspto-grants-2014_07
Patent number
US08765763B2

Reaction notes

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