反应详情

Trifluoroacetonitrile was added to a solution of trans-N-(7-chloro-2,3,4,14b-tetrahydro-1H-dibenzo[b,f]pyrido[1,2-d][1,4]oxazepin-1-yl)-2,2,2-trifluoroacetamide (10 mg, 0.03 mmol) in 2 mL of THF for 2 h. The mixture was stirred at room temperature for 16 hr. After evaporation the crude compound was chromatographed on silica. Elution with toluene gave trans-N-(7-chloro-2,3,4,14b-tetrahydro-1H-dibenzo[b,f]pyrido[1,2-d][1,4]oxazepin-1-yl)-2,2,2-trifluoroacetimidamide (7.14 mg, 55%). Data: (m/z)=396 (M+H)+.

1. customAfter evaporation the crude compound
2. customwas chromatographed on silica
3. washElution with toluene