Methyl 1-[(tert-butoxycarbonyl)amino]cycloheptanecarboxylate → tert-Butyl 16-oxo-6,15-diazadispiro[4.2.6.2]hexadecane-6-carboxylate

HRID 1615838Notes

Reaction equation

HRID 1615838 reaction equation
[C:1]([O:5][C:6](=[O:20])[NH:7][C:8]([C:12]1[CH:17]=[C:16](F)[CH:15]=C(F)C=1)(C)[CH:9]=[O:10])([CH3:4])([CH3:3])[CH3:2].C(OC([NH:28][C:29]1([C:36](OC)=O)[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]1)=O)(C)(C)C>>[O:10]=[C:9]1[C:8]2([CH2:12][CH2:17][CH2:16][CH2:15]2)[N:7]([C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:20])[CH2:36][C:29]2([CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]2)[NH:28]1

Participants

3

Reactant 2

HCID 59614777Methyl 1-[(tert-butoxycarbonyl)amino]cycloheptanecarboxylateHCID 86616399tert-butyl N-[2-(3,5-difluorophenyl)-1-oxopropan-2-yl]carbamate

Product 1

HCID 66865409tert-Butyl 16-oxo-6,15-diazadispiro[4.2.6.2]hexadecane-6-carboxylate

Procedure

Essentially following the procedures described for Intermediate 1, but using methyl 1-[(tert-butoxycarbonyl)amino]cycloheptanecarboxylate in place of tert-butyl 2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propanoate, the title compound was obtained. MS: m/z=337 (M+1).

Sources & evidence

ORD record
ord-5b769e47a055491481616d2a7be0f282
Source dataset
uspto-grants-2014_07
Patent number
US08765759B2

Reaction notes

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