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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1615978Generated: November 1, 2026

6-(1H-Indol-4-yl)-1-methyl-4-nitro-1H-indazole → 6-(1H-Indol-4-yl)-1-methyl-1H-indazol-4-amine

https://huagongshe.com/reaction/1615978

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-(1H-Indol-4-yl)-1-methyl-4-nitro-1H-indazoleHCID 58267990—
CatalystPalladiumHCID 23938—
SolventEthyl AcetateHCID 8857—
Product6-(1H-Indol-4-yl)-1-methyl-1H-indazol-4-amineHCID 58268023157%

Reaction Steps

6-(1H-Indol-4-yl)-1-methyl-4-nitro-1H-indazole (49 mg, 0.17 mmol) was dissolved in ethyl acetate (10 ml) and treated with 10% Pd/C (5 mg) then stirred under hydrogen for 2 h before stirring under nitrogen over the weekend. The reaction was filtered through a Celite cartridge, washing with ethyl acetate, then evaporated to dryness to give the title compound (70 mg) as a grey solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08765743B2
Source datasetuspto-grants-2014_07
ORD IDord-a1d29d93a55e4fcc90747150e8e20905
Source noteuspto-grants-2014_07