反应详情

6-(1H-Indol-4-yl)-1-methyl-1H-indazol-4-amine (70 mg, 0.27 mmol) was dissolved in DCM (3 ml) and treated with DIPEA (0.145 ml). 2-Pyridinecarbonyl chloride hydrochloride (59.5 mg, 0.34 mmol) was added and the reaction was stirred for 5 h. MeOH (2 ml) was added and the reaction stirred overnight. The solvent was evaporated and the residue was treated with DCM/Methanol (1:1, 2 ml) then evaporated to dryness. The product was dissolved in DMSO (2 ml) and purified by Mass Directed Automated Preparative HPLC (Method B). Fractions containing product were combined and dried to give the title compound (23 mg).

1. stirringthe reaction stirred overnight
2. customThe solvent was evaporated
3. additionthe residue was treated with DCM/Methanol (1:1, 2 ml)
4. customthen evaporated to dryness
5. dissolutionThe product was dissolved in DMSO (2 ml)
6. custompurified by Mass Directed Automated Preparative HPLC (Method B)
7. additionFractions containing product
8. customdried