反应详情

温度

160 °C

6-Chloro-3-fluoro-N-[6-(1H-indol-4-yl)-1H-indazol-4-yl]-2-pyridinecarboxamide (50 mg, 0.12 mmol) was placed in a microwave vial and dissolved in piperidine (0.5 ml). The mixture was heated at 160° C. for 1 h under microwave irradiation. The solvent was removed under a stream of nitrogen to give a crude residue that was dissolved in DMSO/MeOH (1:1) and purified by Mass Directed Automated Preparative HPLC (Method C). The product was loaded onto a 1 g aminopropyl column, eluted with MeOH and the solvent removed under a stream of nitrogen to give the title compound (7 mg) as a yellow solid.

1. customThe solvent was removed under a stream of nitrogen
2. customto give a crude residue that
3. custompurified by Mass Directed Automated Preparative HPLC (Method C)
4. washeluted with MeOH
5. customthe solvent removed under a stream of nitrogen