反应详情

To a solution of methyl 2-{3-[(tert-butoxycarbonyl)amino]benzyl}-1-oxo-1,2-dihydroisoquinoline-7-carboxylate (0.23 g, 0.57 mmol) in methylene chloride (5 mL) was added 4.0 M hydrochloric acid in 1,4-dioxane (7 mL, 28 mmol). The reaction mixture was stirred at rt for 2 h. The reaction mixture was concentrated to dryness to afford methyl 2-(3-aminobenzyl)-1-oxo-1,2-dihydroisoquinoline-7-carboxylate.HCl (0.20 g, quant.). LC-MS: (FA) ES+ 309.

1. concentrationThe reaction mixture was concentrated to dryness