Divinyl sulfone → HCID 86691847, compound

HRID 1616233Notes

Reaction equation

HRID 1616233 reaction equation
[NH2:1][C@@H:2]([C:4]1[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[C:6]([C:12]2[N:17]=[C:16]3[N:18]([CH3:27])[C:19](=[O:26])[N:20]([CH2:21][C:22]([CH3:25])([CH3:24])[CH3:23])[C:15]3=[CH:14][CH:13]=2)[CH:5]=1)[CH3:3].[CH:28]([S:30]([CH:33]=[CH2:34])(=[O:32])=[O:31])=[CH2:29]>C(O)C>[CH3:24][C:22]([CH3:23])([CH3:25])[CH2:21][N:20]1[C:15]2[C:16](=[N:17][C:12]([C:6]3[CH:5]=[C:4]([C@H:2]([N:1]4[CH2:34][CH2:33][S:30](=[O:32])(=[O:31])[CH2:28][CH2:29]4)[CH3:3])[CH:11]=[CH:10][C:7]=3[C:8]#[N:9])=[CH:13][CH:14]=2)[N:18]([CH3:27])[C:19]1=[O:26]

Participants

4

Reactant 2

HCID 6496Divinyl sulfoneHCID 86691848HCID 86691848, compound

Product 1

HCID 86691847HCID 86691847, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 38-4 (20 mg, 0.055 mmol) in ethanol (0.3 mL) at room temperature was added (ethenylsulfonyl)ethene (0.011 mL, 13 mg, 0.11 mmol). After 1 hour, the reaction was filtered and purified by reverse phase chromatography (1-100%, 0.1% TFA in H2O/Acetonitrile) to give desired product. MS (M+H)+: observed=482.2212, calculated=482.2220.

Workup

  1. filtrationthe reaction was filtered
  2. custompurified by reverse phase chromatography (1-100%, 0.1% TFA in H2O/Acetonitrile)

Sources & evidence

ORD record
ord-3bddf7aac20941be93ca3ba0df5cfa7a
Source dataset
uspto-grants-2014_07
Patent number
US08765784B2

Reaction notes

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