Trifluoroacetic acid → HCID 178448279, compound

HRID 1616310Notes

Reaction equation

HRID 1616310 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:8][C@@H:9]([NH:13][C:14]1[N:22]=[C:21]2[C:17]([N:18]=[C:19]([O:29][CH3:30])[N:20]2C2CCCCO2)=[C:16]([NH2:31])[N:15]=1)[CH2:10][CH2:11][CH3:12]>CO>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:8][C@@H:9]([NH:13][C:14]1[NH:22][C:21]2[C:17]([N:18]=[C:19]([O:29][CH3:30])[N:20]=2)=[C:16]([NH2:31])[N:15]=1)[CH2:10][CH2:11][CH3:12]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59252563HCID 59252563, compound

Product 1

HCID 178448279HCID 178448279, compoundYield 103.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Trifluoroacetic acid (1 ml, 1.48 g, 7.08 mmol) was added to a stirred solution of N2-[(1R)-1-methylbutyl]-8-(methyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-2,6-diamine (0.613 g, 1.833 mmol) in methanol (10 ml). The resultant mixture was stirred for 66 hours under an atmosphere of nitrogen and then evaporated to give the title compound as an off-white solid (0.690 g).

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-bce1b1a97e3c4781b7095e4475e7c515
Source dataset
uspto-grants-2014_07
Patent number
US08765772B2

Reaction notes

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