2-Aminothiazole → HCID 178522581, compound

HRID 1616527Notes

Reaction equation

HRID 1616527 reaction equation
Cl[C:2]1[C:3]([C:9]([OH:11])=O)=[N:4][C:5](Cl)=[CH:6][CH:7]=1.[NH2:12][C:13]1[S:14][CH:15]=[CH:16][N:17]=1.[CH:18]1([C:21]2[N:26]=[CH:25][C:24]([SH:27])=[CH:23][CH:22]=2)[CH2:20][CH2:19]1.[SH:28][C:29]1[N:33]=[CH:32][NH:31][N:30]=1>>[CH:18]1([C:21]2[N:26]=[CH:25][C:24]([S:27][C:2]3[C:3]([C:9]([NH:12][C:13]4[S:14][CH:15]=[CH:16][N:17]=4)=[O:11])=[N:4][C:5]([S:28][C:29]4[NH:33][CH:32]=[N:31][N:30]=4)=[CH:6][CH:7]=3)=[CH:23][CH:22]=2)[CH2:20][CH2:19]1

Participants

5

Reactant 4

HCID 21552-AminothiazoleHCID 15553ClopyralidHCID 23092621HCID 23092621, compoundHCID 178527894HCID 178527894, compound

Product 1

HCID 178522581HCID 178522581, compound

Procedure

Compound of Production Example 110 can be produced by the same method as Production Example 1, by a method according thereto, or by a combination of these and ordinary methods, with the use of 3,6-dichloro-2-pyridinecarboxylic acid, 2-amino-thiazole, 6-cyclopropyl-3-mercapto-pyridine and 3-mercapto-1,2,4-triazole. 1HNMR(CDCl3)δ:0.70-1.38(4H,m),1.98-2.18(1H,m),6.96-7.08(2H,m),7.46(1H,d,J=3.2 Hz),7.70(1H,dd,J=2.0, 8.4 Hz),8.36(1H,s),8.56 (1H,d,J=2.0 Hz)

Workup

  1. customCompound of Production Example 110 can be produced by the same method as Production Example 1, by a method

Sources & evidence

ORD record
ord-664feb96371e4979b465482a218080a0
Source dataset
uspto-grants-2014_07
Patent number
US08765789B2

Reaction notes

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