Hydrochloric Acid → Hydrochloric Acid

HRID 1616660Notes

Reaction equation

HRID 1616660 reaction equation
[ClH:1].C(OC([N:9]1[CH2:16][CH2:15][C:14]2([CH3:20])[C:17]([CH3:19])([CH3:18])[CH:10]1[CH2:11][C:12]1[CH:24]=[C:23]3[O:25][CH2:26][O:27][C:22]3=[CH:21][C:13]=12)=O)(C)(C)C>ClCCl>[CH2:26]1[O:25][C:23]2[C:22](=[CH:21][C:13]3[C:14]4([CH3:20])[C:17]([CH3:18])([CH3:19])[CH:10]([NH:9][CH2:16][CH2:15]4)[CH2:11][C:12]=3[CH:24]=2)[O:27]1.[ClH:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 58123694HCID 58123694, compound

Product 2

HCID 313Hydrochloric AcidHCID 58123980HCID 58123980, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Isopropanolic hydrochloric acid (5 mol/L, 0.55 mL) is added to 8,9-methylenedioxy-6,11,11-trimethyl-1,2,5,6-tetrahydro-4H-2,6-methano-benzo[d]azocine-3-carboxylic acid tert-butyl ester (0.19 g) dissolved in dichloromethane (2 mL). The resulting solution is stirred for 2 h at room temperature. Then, the solution is concentrated under reduced pressure to give the title product as its hydrochloric acid salt.

Workup

  1. concentrationThen, the solution is concentrated under reduced pressure

Sources & evidence

ORD record
ord-f867fa817d284c5388f3c449b1535fdb
Source dataset
uspto-grants-2014_07
Patent number
US08765780B2

Reaction notes

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