Ethyl Bromide → HCID 86673693, compound

HRID 1616896Notes

Reaction equation

[C:1]1(S(C2C=CC3C4CCN(CCO)CC=4OC=3C=2)(=O)=O)C=CC=C[CH:2]=1.[C:26]1([CH2:32][S:33]([O:36][C:37]2[CH:38]=[CH:39][C:40]3[O:49][CH:44]4[CH2:45][NH:46][CH2:47][CH2:48][C:43]4([CH3:50])[C:41]=3[CH:42]=2)(=[O:35])=[O:34])[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.BrCC>>[C:26]1([CH2:32][S:33]([O:36][C:37]2[CH:38]=[CH:39][C:40]3[O:49][CH:44]4[CH2:45][N:46]([CH2:1][CH3:2])[CH2:47][CH2:48][C:43]4([CH3:50])[C:41]=3[CH:42]=2)(=[O:35])=[O:34])[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1

Participants

Reactant 3

HCID 6332Ethyl Bromide

HCID 53327022HCID 53327022, compound

HCID 86673694HCID 86673694, compound

Product 1

HCID 86673693HCID 86673693, compound

Procedure

Prepared as described for 2-[7-(phenylsulfonyl)-3,4-dihydro[1]benzofuro[2,3-c]pyridin-2(1H)-yl]ethanol (Example 592) starting from 4a-methyl-1,2,3,4,4a,9a-hexahydro[1]benzofuro[2,3-c]pyridin-6-yl phenylmethanesulfonate (Example 757) and bromoethane. MS m/z 388 [M+H]+

Workup

customPrepared

Sources & evidence

ORD record: ord-702722a3e58b48f99692eee1c79e551c
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765779B2

Reaction notes

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