HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 5-(3-Aminopropyl)-6-methyl-N4-pentylpyrimidine-2,4-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | tert-Butyl 3-(2-amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)propylcarbamate | HCID 86633392 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-(3-Aminopropyl)-6-methyl-N4-pentylpyrimidine-2,4-diamine | HCID 9837870 | 84.6% |
Reaction Steps
The product from step (iv) (3.8 g) was dissolved in DCM (100 mL) and TFA (35 mL) and the reaction mixture stirred at rt for 16 h. The solvent was evaporated and the residue taken up in MeOH. The product was purified via SCX resin to give the subtitle compound 2.3 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765939B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-6223fbed4dd548d38224e306f12a9cb3 |
| Source note | uspto-grants-2014_07 |