反应详情

The product from step (viii) (76 mg) was dissolved in DCM (5 mL) and TFA (5 mL) and the mixture stirred at rt for 1 h. The solvent was evaporated and the crude material dissolved in MeOH (5 mL) and purified by SCX. The product was dissolved in THF (10 mL) then lithium hydroxide (12.2 mg) in water (5 mL) was added. The reaction mixture was heated to reflux for 1 h, the solvents were evaporated and the crude product purified by RPHPLC to afford the subtitle product 40 mg.

1. customThe solvent was evaporated
2. dissolutionthe crude material dissolved in MeOH (5 mL)
3. custompurified by SCX
4. dissolutionThe product was dissolved in THF (10 mL)
5. additionlithium hydroxide (12.2 mg) in water (5 mL) was added
6. temperatureThe reaction mixture was heated
7. temperatureto reflux for 1 h
8. customthe solvents were evaporated
9. customthe crude product purified by RPHPLC