Carbonic acid-guanidine (1:1) → HCID 178433373, compound

HRID 1617186Notes

Reaction equation

HRID 1617186 reaction equation
O=[C:2]([CH3:24])[CH:3]([CH2:9][C:10]1[CH:15]=[CH:14][C:13]([CH2:16][O:17][CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][O:19]2)=[CH:12][CH:11]=1)[C:4](OCC)=[O:5].C(=O)(O)O.[NH2:29][C:30]([NH2:32])=[NH:31]>CCO>[NH2:32][C:30]1[N:31]=[C:4]([OH:5])[C:3]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([CH2:16][O:17][CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][O:19]3)=[CH:12][CH:11]=2)=[C:2]([CH3:24])[N:29]=1

Participants

4

Reactant 2

HCID 286947Carbonic acid-guanidine (1:1)HCID 68414491Ethyl 3-oxo-2-(4-((tetrahydro-2H-pyran-2-yloxy)methyl)benzyl)butanoate

Product 1

HCID 178433373HCID 178433373, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of the product from step (i) (15.66 g) and guanidine carbonate (8.7 g) in EtOH (150 ml) was heated under reflux for 48 h. The mixture was cooled, the solvent removed under reduced pressure and the residue triturated with water. The solid was filtered, washed with water then diethylether and dried to afford the subtitle compound, 11.58 g.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 48 h
  3. temperatureThe mixture was cooled
  4. customthe solvent removed under reduced pressure
  5. customthe residue triturated with water
  6. filtrationThe solid was filtered
  7. washwashed with water
  8. dry with materialdiethylether and dried

Sources & evidence

ORD record
ord-30a6ae84f24c41409a750b0b712534ba
Source dataset
uspto-grants-2014_07
Patent number
US08765939B2

Reaction notes

Loading…