HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbonic acid-guanidine (1:1) → HCID 178433373, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbonic acid-guanidine (1:1) | HCID 286947 | — |
| Reactant | Ethyl 3-oxo-2-(4-((tetrahydro-2H-pyran-2-yloxy)methyl)benzyl)butanoate | HCID 68414491 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178433373 | HCID 178433373 | — |
Reaction Steps
A mixture of the product from step (i) (15.66 g) and guanidine carbonate (8.7 g) in EtOH (150 ml) was heated under reflux for 48 h. The mixture was cooled, the solvent removed under reduced pressure and the residue triturated with water. The solid was filtered, washed with water then diethylether and dried to afford the subtitle compound, 11.58 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765939B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-30a6ae84f24c41409a750b0b712534ba |
| Source note | uspto-grants-2014_07 |