HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (4-((2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)phenyl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 6-Methyl-N4-pentyl-5-(4-((tetrahydro-2H-pyran-2-yloxy)methyl)benzyl)pyrimidine-2,4-diamine | HCID 68415422 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (4-((2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)phenyl)methanol | HCID 68416750 | — |
Reaction Steps
2M HCl (10 ml) was added to a stirred solution of the product from step (iv) (3.4 g) in MeOH (30 ml). The mixture was stirred at rt for 3 days then the solvent evaporated under reduced pressure. The residue was partitioned between DCM/aq NaHCO3 solution, the organics separated, dried and evaporated under reduced pressure to afford the subtitle compound, 2.38 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765939B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-adf1e21031d446b2aedacbbd657359a3 |
| Source note | uspto-grants-2014_07 |