Hydrochloric Acid → (4-((2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)phenyl)methanol

HRID 1617189Notes

Reaction equation

HRID 1617189 reaction equation
Cl.[CH3:2][C:3]1[N:8]=[C:7]([NH2:9])[N:6]=[C:5]([NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[C:4]=1[CH2:16][C:17]1[CH:22]=[CH:21][C:20]([CH2:23][O:24]C2CCCCO2)=[CH:19][CH:18]=1>CO>[NH2:9][C:7]1[N:8]=[C:3]([CH3:2])[C:4]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([CH2:23][OH:24])=[CH:19][CH:18]=2)=[C:5]([NH:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 684154226-Methyl-N4-pentyl-5-(4-((tetrahydro-2H-pyran-2-yloxy)methyl)benzyl)pyrimidine-2,4-diamine

Product 1

HCID 68416750(4-((2-Amino-4-methyl-6-(pentylamino)pyrimidin-5-yl)methyl)phenyl)methanol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2M HCl (10 ml) was added to a stirred solution of the product from step (iv) (3.4 g) in MeOH (30 ml). The mixture was stirred at rt for 3 days then the solvent evaporated under reduced pressure. The residue was partitioned between DCM/aq NaHCO3 solution, the organics separated, dried and evaporated under reduced pressure to afford the subtitle compound, 2.38 g.

Workup

  1. customthe solvent evaporated under reduced pressure
  2. customThe residue was partitioned between DCM/aq NaHCO3 solution
  3. customthe organics separated, dried
  4. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-adf1e21031d446b2aedacbbd657359a3
Source dataset
uspto-grants-2014_07
Patent number
US08765939B2

Reaction notes

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