反应详情

温度

100 °C

A mixture of the product from step (i) (20 g), tetramethyltin (20 ml) and tetrakis(triphenylphosphine)palladium (0) (2 g) in DMF (200 ml) was heated at 100° C. for 16 h then evaporated under reduced pressure. The residue was partitioned between EtOAc/brine, the organics separated, dried and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 50-60% EtOAc/isohexane to afford the subtitle compound, 14.4 g.

1. customthen evaporated under reduced pressure
2. customThe residue was partitioned between EtOAc/brine
3. customthe organics separated, dried
4. customevaporated under reduced pressure
5. customThe residue was purified by chromatography on silica eluting with 50-60% EtOAc/isohexane