Hydrochloric Acid → HCID 178433374, compound

HRID 1617203Notes

Reaction equation

HRID 1617203 reaction equation
Cl.[NH2:2][C:3]1[N:8]=[C:7]([OH:9])[C:6]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([CH2:17][O:18]C3CCCCO3)=[CH:13][CH:12]=2)=[C:5]([CH3:25])[N:4]=1>CO>[NH2:2][C:3]1[N:8]=[C:7]([OH:9])[C:6]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([CH2:17][OH:18])=[CH:13][CH:12]=2)=[C:5]([CH3:25])[N:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178433373HCID 178433373, compound

Product 1

HCID 178433374HCID 178433374, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Conc. HCl (4 ml) was added to a mixture of the product from example 34 step (ii) (5.2 g) in MeOH (100 ml) at rt and stirred for 30 min. The solvent was evaporated under reduced pressure and the residue dissolved in water (150 ml). Aq sat. NaHCO3 soln was added until basic then the solid filtered, washed with water, ether and dried to afford the subtitle compound, 3.48 g.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. dissolutionthe residue dissolved in water (150 ml)
  3. additionAq sat. NaHCO3 soln was added until basic then the solid
  4. filtrationfiltered
  5. washwashed with water, ether
  6. customdried

Sources & evidence

ORD record
ord-55df643e91144d8ca7d1877d70c3135f
Source dataset
uspto-grants-2014_07
Patent number
US08765939B2

Reaction notes

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