HuagongsheHuagongshe Chemistry Print Report · For research reference only
Butylamine → 2-(4-((2-Amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)phenyl)acetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Butylamine | HCID 8007 | — |
| Reactant | 2-Amino-5-(4-(cyanomethyl)benzyl)-6-methylpyrimidin-4-yl 2,4,6-trimethylbenzenesulfonate | HCID 86633409 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-(4-((2-Amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)phenyl)acetonitrile | HCID 68414428 | — |
Reaction Steps
A mixture of the product from step (iv) (0.3 g) and butylamine (1 ml) in 1,4-dioxane (6 ml) was sealed into a microwave tube and the reaction was performed in the CEM Microwave, at 160° C. and 100 W for 1 h. The solvent was evaporated under reduced pressure and the residue used crude in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08765939B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-6e95f4029c0a467d98e405da549b65f4 |
| Source note | uspto-grants-2014_07 |