反应详情

To 2-amino-4,6-dichloropyrimidine-5-carbaldehyde (30 g) in MeOH (600 ml) and TEA (22 ml), pentylamine (18.5 ml) was added and heated at reflux for 3 h. The solvent was removed and the residue partitioned between EtOAc and water, the organic layer was dried and the solvent evaporated. The residue was triturated with ether/isohexane to give the subtitle compound as a solid, 20.2 g.

1. temperatureheated
2. temperatureat reflux for 3 h
3. customThe solvent was removed
4. customthe residue partitioned between EtOAc and water
5. customthe organic layer was dried
6. customthe solvent evaporated
7. customThe residue was triturated with ether/isohexane