Pentylamine → 2-Amino-4-chloro-6-(pentylamino)pyrimidine-5-carbaldehyde

Participants

Reaction Steps

To 2-amino-4,6-dichloropyrimidine-5-carbaldehyde (30 g) in MeOH (600 ml) and TEA (22 ml), pentylamine (18.5 ml) was added and heated at reflux for 3 h. The solvent was removed and the residue partitioned between EtOAc and water, the organic layer was dried and the solvent evaporated. The residue was triturated with ether/isohexane to give the subtitle compound as a solid, 20.2 g.

Provenance & Evidence