Hydrochloric Acid → Methyl 2-(4-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-3-hydroxyphenyl)acetate

HRID 1617227노트

반응식

HRID 1617227 반응식
[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:5]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][C:21]([OH:23])=[O:22])=[CH:16][C:15]=2[O:24]C)=[C:4]([CH3:26])[N:3]=1.[CH3:27]O.Cl>C(Cl)Cl.B(Br)(Br)Br.O1CCOCC1>[NH2:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][CH2:11][CH3:12])[C:5]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([CH2:20][C:21]([O:23][CH3:27])=[O:22])=[CH:16][C:15]=2[OH:24])=[C:4]([CH3:26])[N:3]=1

참가 물질

7

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 684141782-(4-((2-Amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-3-methoxyphenyl)acetic acid

생성물 1

HCID 42613680Methyl 2-(4-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-3-hydroxyphenyl)acetate

시약·촉매·용매 3

HCID 6344Dichloromethane용매HCID 25134Boron tribromide용매HCID 312751,4-Dioxane용매

실험 절차

To the product from example 72 step (i) (550 mg) in DCM (20 mL), BBr3 (0.29 ml) was added dropwise and the reaction mixture stirred for 5 h. MeOH (4 mL) was added followed by 4M HCl in dioxane (0.5 mL) and stirred for 16 h and the solvents evaporated. The residue was purified by RPHPLC to give the title compound as a white solid, 8 mg.

후처리

  1. stirringstirred for 16 h
  2. customthe solvents evaporated
  3. customThe residue was purified by RPHPLC

출처 및 근거

ORD 기록
ord-a9a8e596245c416ba35482f0a56a6bc5
출처 데이터셋
uspto-grants-2014_07
특허 번호
US08765939B2

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