HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1617240Generated: October 25, 2026
Hydrochloric Acid → (1-Methylpiperidin-4-yl)methyl 2-(3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-4-methoxyphenyl)acetate
https://huagongshe.com/reaction/1617240
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-Methyl-4-piperidinemethanol | HCID 271971 | — |
| Reactant | Methyl 2-(3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-4-methoxyphenyl)acetate | HCID 42613821 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (1-Methylpiperidin-4-yl)methyl 2-(3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-4-methoxyphenyl)acetate | HCID 42613685 | — |
Reaction Steps
4M HCl in dioxane (1.5 mL) was added to a mixture of the product from step (v) (300 mg) and (1-methylpiperidin-4-yl)methanol (520 mg). The suspension was heated at 80° C. for 24 h and the solvent evaporated under reduced pressure. The residue was purified by RPHPLC to give the title compound as a gum, 10 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08765939B2 |
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| Source dataset | uspto-grants-2014_07 |
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| ORD ID | ord-094f84c1403d4f4b8fbc8ed02ad0060c |
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| Source note | uspto-grants-2014_07 |
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