Hydrochloric Acid → (1-Methylpiperidin-4-yl)methyl 2-(3-((2-amino-4-(butylamino)-6-methylpyrimidin-5-yl)methyl)-4-methoxyphenyl)acetate

HRID 1617240Notes

Reaction equation

Cl.[NH2:2][C:3]1[N:8]=[C:7]([NH:9][CH2:10][CH2:11][CH2:12][CH3:13])[C:6]([CH2:14][C:15]2[CH:16]=[C:17]([CH2:23][C:24]([O:26][CH3:27])=[O:25])[CH:18]=[CH:19][C:20]=2[O:21][CH3:22])=[C:5]([CH3:28])[N:4]=1.[CH3:29][N:30]1[CH2:35][CH2:34][CH:33](CO)[CH2:32][CH2:31]1>O1CCOCC1>[NH2:2][C:3]1[N:8]=[C:7]([NH:9][CH2:10][CH2:11][CH2:12][CH3:13])[C:6]([CH2:14][C:15]2[CH:16]=[C:17]([CH2:23][C:24]([O:26][CH2:27][CH:33]3[CH2:34][CH2:35][N:30]([CH3:29])[CH2:31][CH2:32]3)=[O:25])[CH:18]=[CH:19][C:20]=2[O:21][CH3:22])=[C:5]([CH3:28])[N:4]=1

Participants

Conditions

Temperature: 80 °C

Procedure

4M HCl in dioxane (1.5 mL) was added to a mixture of the product from step (v) (300 mg) and (1-methylpiperidin-4-yl)methanol (520 mg). The suspension was heated at 80° C. for 24 h and the solvent evaporated under reduced pressure. The residue was purified by RPHPLC to give the title compound as a gum, 10 mg.

Workup

customthe solvent evaporated under reduced pressure
customThe residue was purified by RPHPLC

Sources & evidence

ORD record: ord-094f84c1403d4f4b8fbc8ed02ad0060c
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765939B2

Reaction notes

Loading…