Pentylamine → HCID 68955280, compound

HRID 1617242Notes

Reaction equation

HRID 1617242 reaction equation
[NH2:1][C:2]1[N:7]=[C:6](Cl)[C:5]([CH2:9][C:10]2[CH:11]=[C:12]([CH2:16][C:17]#[N:18])[CH:13]=[CH:14][CH:15]=2)=[C:4]([CH3:19])[N:3]=1.[CH2:20]([NH2:25])[CH2:21][CH2:22][CH2:23][CH3:24]>C(O)CCC>[NH2:1][C:2]1[N:3]=[C:4]([CH3:19])[C:5]([CH2:9][C:10]2[CH:11]=[C:12]([CH2:16][C:17]#[N:18])[CH:13]=[CH:14][CH:15]=2)=[C:6]([NH:25][CH2:20][CH2:21][CH2:22][CH2:23][CH3:24])[N:7]=1

Participants

4

Reactant 2

HCID 8060PentylamineHCID 86633416HCID 86633416, compound

Product 1

HCID 68955280HCID 68955280, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Conditions

Temperature
110 °C

Procedure

The product from step (iii) (Ig) was combined with butan-1-ol (25 mL) and pentan-1-amine (4 mL) was added. The reaction mixture was heated to 110° C. for 18 h. The solvents were evaporated and the product purified using chromatography to give the subtitle compound as an orange oil, 600 mg.

Workup

  1. additionwas added
  2. customThe solvents were evaporated
  3. customthe product purified

Sources & evidence

ORD record
ord-f82164e5168d4efb9b3c5815484b0889
Source dataset
uspto-grants-2014_07
Patent number
US08765939B2

Reaction notes

Loading…