HCID 86629757, compound → HCID 59382684, compound

HRID 1617276Notes

Reaction equation

HRID 1617276 reaction equation
FC(F)(F)C(O)=O.[C:8]([C:10]1[CH:11]=[C:12]([NH:16][C:17]2[C:26]3[C:21](=[CH:22][CH:23]=[C:24]([NH:27][C:28](=[O:36])[CH:29]=[C:30]4[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]4)[CH:25]=3)[N:20]=[CH:19][N:18]=2)[CH:13]=[CH:14][CH:15]=1)#[CH:9]>C(OCC)(=O)C>[C:8]([C:10]1[CH:11]=[C:12]([NH:16][C:17]2[C:26]3[C:21](=[CH:22][CH:23]=[C:24]([NH:27][C:28](=[O:36])[CH:29]=[C:30]4[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]4)[CH:25]=3)[N:20]=[CH:19][N:18]=2)[CH:13]=[CH:14][CH:15]=1)#[CH:9]

Participants

3

Reactant 1

HCID 86629757HCID 86629757, compound

Product 1

HCID 59382684HCID 59382684, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

N-(4-(3-ethynylphenylamino)quinazolin-6-yl)-2-(piperidin-4-ylidene)acetamide trifluoroacetate was dissolved in ethyl acetate. The mixture was washed once with saturated Na2CO3 and once with brine, dried over anhydrous magnesium sulfate, filtered, and evaporated in vacuo to give the title product. MS (EI) 384 (M+1).

Workup

  1. washThe mixture was washed once with saturated Na2CO3 and once with brine
  2. dry with materialdried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-8a71b03e1823490ea5b0f15db6291945
Source dataset
uspto-grants-2014_07
Patent number
US08765946B2

Reaction notes

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