HCID 68454721, compound → HCID 59382701, compound

HRID 1617280Notes

Reaction equation

HRID 1617280 reaction equation
FC(F)(F)C(O)=O.[Cl:8][C:9]1[CH:10]=[C:11]([NH:23][C:24]2[C:33]3[C:28](=[CH:29][CH:30]=[C:31]([NH:34][C:35](=[O:43])[CH:36]=[C:37]4[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]4)[CH:32]=3)[N:27]=[CH:26][N:25]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1>C(OCC)(=O)C>[Cl:8][C:9]1[CH:10]=[C:11]([NH:23][C:24]2[C:33]3[C:28](=[CH:29][CH:30]=[C:31]([NH:34][C:35](=[O:43])[CH:36]=[C:37]4[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]4)[CH:32]=3)[N:27]=[CH:26][N:25]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1

Participants

3

Reactant 1

HCID 68454721HCID 68454721, compound

Product 1

HCID 59382701HCID 59382701, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)quinazolin-6-yl)-2-(piperidin-4-ylidene)acetamide trifluoroacetate was dissolved in ethyl acetate, washed once with saturated Na2CO3, and once with brine, dried over anhydrous magnesium sulfate, filtered, and evaporated in vacuo to give the title product. MS (EI) 501 (M+1).

Workup

  1. washwashed once with saturated Na2CO3
  2. dry with materialonce with brine, dried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. customevaporated in vacuo

Sources & evidence

ORD record
ord-ba810db87141482ab60c0a22d2e0f11b
Source dataset
uspto-grants-2014_07
Patent number
US08765946B2

Reaction notes

Loading…