2-Fluoro-4-iodo-6-methylpyridine → 1-(2-Fluoro-6-methyl-pyridin-4-yl)-3,3-diphenyl-propan-1-one

HRID 1617481Notes

Reaction equation

HRID 1617481 reaction equation
CON(C)[C:4](=[O:19])[CH2:5][CH:6]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[F:21][C:22]1[CH:27]=[C:26](I)[CH:25]=[C:24]([CH3:29])[N:23]=1>>[F:21][C:22]1[CH:27]=[C:26]([C:4](=[O:19])[CH2:5][CH:6]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:25]=[C:24]([CH3:29])[N:23]=1

Participants

3

Reactant 2

HCID 447547522-Fluoro-4-iodo-6-methylpyridineHCID 54293842N-Methoxy-N-methyl-3,3-diphenyl-propionamide

Product 1

HCID 666663611-(2-Fluoro-6-methyl-pyridin-4-yl)-3,3-diphenyl-propan-1-one

Procedure

In analogy to example 55, step 2, from N-methoxy-N-methyl-3,3-diphenyl-propionamide and 2-fluoro-4-iodo-6-picoline was prepared the title compound as an off-white solid, MS (ESI+): m/z=320.1449 ([M+H]+).

Sources & evidence

ORD record
ord-b459a6e478974dd4b6a3ca5daf32d824
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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