Methanamine, N-methoxy-, hydrochloride (1:1) → 2-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-N-methoxy-N-methyl-acetamide

HRID 1617487Notes

Reaction equation

HRID 1617487 reaction equation
[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[CH:6]([CH2:16][C:17]([OH:19])=O)[C:5]=2[CH:4]=[CH:3][CH:2]=1.Cl.[CH3:21][NH:22][O:23][CH3:24]>>[CH:12]1[C:8]2[CH2:9][CH2:10][C:11]3[CH:1]=[CH:2][CH:3]=[CH:4][C:5]=3[CH:6]([CH2:16][C:17]([N:22]([O:23][CH3:24])[CH3:21])=[O:19])[C:7]=2[CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 81138Methanamine, N-methoxy-, hydrochloride (1:1)HCID 1266909110,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylacetic acid

Product 1

HCID 866609442-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-N-methoxy-N-methyl-acetamide

Procedure

In analogy to example 55, step 1, from 10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-acetic acid (CAS RN: [4037-50-7]) and N,O-dimethylhydroxylamine hydrochloride was prepared the title compound as a colorless oil, MS (ESI+): m/z=296.3 ([M+H]+).

Sources & evidence

ORD record
ord-9d8e9ec99b25469bac4e892c7bb2cd73
Source dataset
uspto-grants-2014_07
Patent number
US08765730B2

Reaction notes

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