4-Iodopyridine → 2-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-1-pyridin-4-yl-ethanone

HRID 1617488Notes

Reaction equation

[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[CH:6]([CH2:16][C:17](N(OC)C)=[O:18])[C:5]=2[CH:4]=[CH:3][CH:2]=1.I[C:24]1[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=1>>[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[CH:6]([CH2:16][C:17]([C:24]3[CH:29]=[CH:28][N:27]=[CH:26][CH:25]=3)=[O:18])[C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 6094924-Iodopyridine

HCID 866609442-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-N-methoxy-N-methyl-acetamide

Product 1

HCID 670155052-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-1-pyridin-4-yl-ethanone

Procedure

In analogy to example 55, step 2, from 2-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-N-methoxy-N-methyl-acetamide and 4-iodopyridine was prepared the title compound as a white solid, MS (ESI+): m/z=314.1 ([M+H]+).

Sources & evidence

ORD record: ord-8176f2e3176b48049ed15ad8b33a783a
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08765730B2

Reaction notes

Loading…