3-Chloro-4-(methoxycarbonyl)benzeneboronic acid → 3-Chloro-4'-[3-(2-methyl-pyridin-4-yl)-3-oxo-1-o-tolyl-propyl]-biphenyl-4-carboxylic acid methyl ester
Reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=2[CH3:25])[CH2:9][C:10]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([CH3:18])[CH:13]=2)=[O:11])=[CH:4][CH:3]=1.B(O)(O)[C:27]1[CH:32]=[CH:31][C:30]([C:33]([O:35][CH3:36])=[O:34])=[C:29]([Cl:37])[CH:28]=1>>[CH3:36][O:35][C:33]([C:30]1[CH:31]=[CH:32][C:27]([C:2]2[CH:3]=[CH:4][C:5]([CH:8]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[CH3:25])[CH2:9][C:10]([C:12]3[CH:17]=[CH:16][N:15]=[C:14]([CH3:18])[CH:13]=3)=[O:11])=[CH:6][CH:7]=2)=[CH:28][C:29]=1[Cl:37])=[O:34]Participants
3
Procedure
In analogy to example 74, step 6, from 3-(4-bromo-phenyl)-1-(2-methyl-pyridin-4-yl)-3-o-tolyl-propan-1-one (example 74, step 5) and (3-chloro-4-methoxycarbonyl)benzeneboronic acid was prepared the title compound as a colorless oil, MS (ESI+): m/z=484.1680 ([M+H]+, 1Cl).
Sources & evidence
- ORD record
- ord-b908a0ca9f0c4e17b56601c6fc367e4a
- Source dataset
- uspto-grants-2014_07
- Patent number
- US08765730B2
Reaction notes
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